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2006 Publications


Journal of Biomolecular Screening 2006; 11(8): 959 – 967
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
Vasantha M. Nayagam, Xukun Wang, Yong Cheng Tan, Anders Poulsen, Kee Chuan Goh, Tony Ng, Haishan Wang, Hong Yan Song, Binhui Ni, Michael Entzeroth and Walter Stunkel

The Royal Society of Chemistry, London 2006
Concepts for in vitro profiling - Drug Activity, Selectivity and Liability. In: Exploiting Chemical Diversity for Drug Discovery
Michael Entzeroth, M.B. Bolger, R. Frackiewcz and B. Steere

18th EORTC-NCI-AACR symposium: "Molecular Targets and Cancer Therapeutics" in Prague, 7-10 November 2006
ADME and PK/PD attributes of SB939, potent orally active HDAC inhibitor
Kanda Sangthongpitag, Haishang Wang, Pauline Yeo, Xin Liu, Evelyn Goh, Lee Sun New, Peizi Zeng, Venkatesh. P, Xiaofeng Wu, Changyong Hu and Kantharaj Ethirajulu

18th EORTC-NCI-AACR symposium: "Molecular Targets and Cancer Therapeutics" in Prague, 7-10 November 2006
Pharmacological profile of SB939, a novel, potent and orally active histone deacetylase inhibitor
Jeanette Wood, Kanda Sangthongpitag, Haishang Wang, Pauline Yeo, Xin Liu, Evelyn Goh, Lee Sun New, Peizi Zeng, Venkatesh. P, Xiaofeng Wu, Changyong Hu and Kantharaj Ethirajulu

(Abstracts of Papers) 232nd ACS National Meeting in San Francisco, CA, USA, 10-14 September 2006, MEDI-575
Oral presentation: Design, synthesis, and SAR of novel benzimidazole based HDAC inhibitors
Haishan Wang

(Abstracts of Papers) 232nd ACS National Meeting in San Francisco, CA, USA, 10-14 September 2006, MEDI-146
Synthesis and SAR of N-hydroxy-1,2-disubstituted-1H-benzoimidazol-5-yl-acrylamides as a novel class of histone deacetylase inhibitors
Haishan Wang, Niefang Yu, Hongyan Song, Dizhong Chen, Weiping Deng, Pek Ling Lye, Yong Zou, Melvin Ng, Joyce Chang, Eric T. Sun, Kanda Sangthongpitag, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Pauline Yeo, Xin Liu, Evelyn Goh, Lee Sun New, Kantharaj Ethirajulu and Michael Entzeroth

9th European ISSX Meeting in Manchester, UK, 4-7 June 2006
Comparative Pharmacokinetics of HDAC Inhibitors in the Pharmacological Species
Pauline Yeo, Liu Xin, Evelyn Goh, Lee Sun New, Peizi Zeng, Xiaofeng Wu, Changyong Hu, Tony Ng, Kanda Sangthongpitag, Haishang Wang, Eric Sun and Kantharaj Ethirajulu

97th Annual AACR meeting in Washington DC, April 2006
Potent Antitumor Activity of N-Hydroxy-3-benzimidazol-5-yl acrylamides
Kanda Sangthongpitag, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Changyong Hu, Pauline Yeo, Xin Liu, Niefang Yu, Haishan Wang, Kantharaj Ethirajulu, Eric T. Sun, and Michael Entzeroth



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