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Ray Bradbury



2007 Publications


Biotechnology Journal 2007; 2(11): 1360 – 1368
Function of the SIRT1 protein deacetylase in cancer
Walter Stunkel, Bee Keow Peh, Yong Cheng Tan, Vasantha M. Nayagam, Xukun Wang, Manuel Salto-Tellez, Binhui Ni, Michael Entzeroth and Jeanette Wood

Biomedical Chromatography 2007; 21(2): 184 – 189
Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies
Pauline Yeo, Liu Xin, Evelyn Goh, Lee Sun New, Peizi Zeng, Xiaofeng Wu, P. Venkatesh and Ethirajulu Kantharaj

Biological and Pharmaceutical Bulletin 2007; 30(5): 1021—1024
In vitro Phase I Cytochrome P450 Metabolism, Permeability and Pharmacokinetics of SB639, a Novel Histone Deacetylase Inhibitor in Preclinical Species
P. Venkatesh, Evelyn Goh, Peizi Zeng, Lee Sun New, Liu Xin, Mohammed Khalid Pasha, Kanda Sangthongpitag, Pauline Yeo, and Ethirajulu Kantharaj

Blood (ASH Annual Meeting Abstracts) Nov 2007; 110: 4201
Pharmacokinetic and Pharmacodynamic Properties of SB1317, a Potent and Orally Active Multi-Kinase Inhibitor
Pauline Yeo, P. Venkatesh, Evelyn Goh, Peizi Zeng, Lee S. New, Changyong Hu, Kanda Sangthongpitag, Anthony D. William, Kee Chuan Goh, Jeanette Wood, and Ethirajulu Kantharaj

Blood (ASH Annual Meeting Abstracts) Nov 2007; 110: 1593
SB1317, a Potent and Orally Active FLT3-CDK Inhibitor with High Anti-Tumor Efficacy in Models of Hematological Malignancies
Kee Chuan Goh, Wai Chung Ong, Changyong Hu, Ai Leng Liang, Walter Stunkel, Yong Cheng Tan, Kanda Sangthongpitag, Siok Kun Goh, Zahid Q. Bonday, Anthony D. William, Brian W. Dymock, Ethirajulu Kantharaj, and Jeanette M. Wood

Blood (ASH Annual Meeting Abstracts) Nov 2007; 110: 538
SB1518: A Potent and Orally Active JAK2 Inhibitor for the Treatment of Myeloproliferative Disorders
Kee Chuan Goh, Wai Chung Ong, Changyong Hu, Hannes Hentze, Ai Leng Liang, Walter Stunkel, Yong Cheng Tan, Kanda Sangthongpitag, Siok K. Goh, Shirly Sieh, Zahid Q. Bonday, Anthony D. William, Angeline Lee, Stephanie Blanchard, Te C. Liu, Martin Sattler, James D. Griffin, Brian W. Dymock, Ethirajulu Kantharaj, and Jeanette M. Wood

Blood (ASH Annual Meeting Abstracts) Nov 2007; 110: 1603
SB939: A Potent and Orally Active HDAC Inhibitor for the Treatment of Hematological Malignancies
Kanda Sangthongpitag, Walter Stunkel, Zahid Q. Bonday, Kee C. Goh, Xukun Wang, Xiaofeng Wu, Changyong Hu, Haishan Wang, Niefang Yu, Eric Sun, Michael Entzeroth, Ethirajulu Kantharaj, Chien-Shing Chen, and Jeanette M. Wood

AACR Centennial Conference on Translational Cancer Medicine in Singapore, November 2007
SB939: a potent, orally-active HDAC inhibitor for the treatment of hematological malignancies and solid tumors
K. Sangthongpitag, H. Wang, W. Stünkel, Z. Bonday, Y. C. Tan, V. M. Nayagam, S. K. Goh, K.C. Goh, W. Xukun, X. Wu, C. Hu, E. Sun, M. Entzeroth, P. Venkatesh, E. Goh, P. Yeo, C.S. Chen, G. Greicius, S. Pettersson, E. Kantharaj and J. Wood

AACR-NCI-EORTC conference on Molecular Targets in San Francisco, October 2007
SB939: a potent and orally active HDAC inhibitor for the treatment of colorectal cancer
K. Sangthongpitag, G. Greicius, W. Stunkel, K.P. Koh, Y. C. Tan, V.M. Nayagam, Z. Bonday, M. K. Goh, C. P. Ng, K.C. Goh, X.K. Wang, K.L. Goh, W.C. Ong, X.F Wu, C.Y. Hu, H. H. Khng, S. K. Goh, T. Ng, M. Entzeroth, H.S. Wang, N.F Yu, K. Lee, D.Z. Chen, P.L. Lye, J. Chang, M. Ng,
W.P. Deng, M. L. Khoo, T. Lu, C.K. Soh, E.T. Sun, P. Yeo, X. Liu, E. Goh, L.S. New, E. Kantharaj, S. Pettersson and J. Wood

8th International ISSX Meeting in Sendai in Japan, 9–12 October 2007
Development of generic LC-MS-MS cocktail analysis method for the characterization of both cytochrome P450 inhibition and phenotyping properties of new chemical entities (NCEs) using Qtrap 3200 system
Pauline Yeo, Evelyn Goh, Lee Sun New, Peizi Zeng, Venkatesh. P, Ethirajulu Kantharaj

ACS-EFMC Meeting in Siena, Italy , October 2007
Indazoles as potent and selective aurora kinase inhibitors
Stéphanie Blanchard, Zahid Bonday, Kay Lin Goh, Kee Chuan Goh, Angeline Lee, Wai Chung Ong, Anders Poulsen, Eric Sun, Ee Ling Teo, Anthony William

Rosenön Meeting 2007: “DMPK and PK/PD from Lead to Product - Recent Developments and Trends in an Expanding Science” in Stockholm, Sweden, 20 – 22 September 2007
Pharmacokinetic-pharmacodynamic (PK-PD) relationship of novel HDAC inhibitors in HCT116 mouse xenograft tumor model
Pauline Yeo, Evelyn Goh, Peizi Zeng, Venkatesh. P, Ethirajulu Kantharaj

CHI's Fifth Annual Protein Kinase Targets in Boston, June 2007
Indazoles as potent and selective aurora kinase inhibitors
Stéphanie Blanchard, Zahid Bonday, Kay Lin Goh, Kee Chuan Goh, Angeline Lee, Wai Chung Ong, Anders Poulsen, Eric Sun, Ee Ling Teo, Anthony William



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