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2008 Publications


Journal of Computer-Aided Molecular Design 2008; 22(12): 897 – 906
Structure-based design of Aurora A & B inhibitors
Anders Poulsen, Anthony William, Angeline Lee, Stephanie Blanchard, Eeling Teo, Weiping Deng, Noah Tu, Evelyn Tan, Eric Sun, Kay Lin Goh, Wai Chung Ong, Chee Pang Ng, Kee Chuan Goh and Zahid Bonday

EORTC conference in Geneva, October 2008
SB939 chemistry: Discovery of SB939, an HDAC inhibitor with a superior preclinical profile (Abstract No. 136)
Haishan Wang, Niefang Yu, Dizhong Chen, Eric T Sun, Kanda Sangthongpitag, Zahid Bonday, Pauline Yeo, Kantharaj Ethirajulu, Jeanette Wood and Brian Dymock

EORTC conference in Geneva, October 2008
SB939 Phase 1 Study: A phase I dose escalation study of oral SB939 when administered thrice weekly (every other day) for 3 weeks in a 4-week cycle in patients with advanced solid malignancies (Abstract No. 413)
Wei-Peng Yong, Boon-Cher Goh, Kantharaj Ethirajulu, Pauline Yeo, Odette Otheris, Siew Mien Chao, Ross Soo, Wee-Lee Yeo, Elaine Seah and Joy Zhu

EORTC conference in Geneva, October 2008
SB939 Biomarker results: A robust and quantitative biomarker assay for SB939, a potent, orally-active HDAC inhibitor (Abstract No. 83)
Veronica Novotny-Diermayr, Vasantha M. Nayagam, Hannes Hentze, Ai Leng Liang, Nina Sausgruber, Pauline Yeo, Kantharaj Ethirajulu, and Jeanette Wood

UK-Singapore Medicinal Chemistry Symposium at Biopolis in Singapore, 16th October 2008
SB939 Oral Presentation: “SB939: the story of Singapore’s first home-grown small molecule oncology drug”
Brian Dymock



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