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The best scientist is open to experience and begins with romance - the idea that anything is possible. Ray Bradbury |
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Publications Bioorganic & Medicinal Chemistry Letters 2010; Jun 1; 20(11); 3314-21. Epub 2010 Apr 14. Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity Haishan Wang, Ze-Yi Lim, Yan Zhou, Melvin Ng, Ting Lu, Ken Lee, Kanda Sangthongpitag, Kee Chuan Goh, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Wai Chung Ong, Zahid Bonday, Eric T. Sun Bioorganic & Medicinal Chemistry Letters 2010; Apr 15; 20(8); 2443-7. Epub 2010 Mar 7 Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors Stèphanie Blanchard, Anthony William, Angeline Lee, Anders Poulson, Ee Ling Teo, Weiping Deng, Noah Tu, Evelyn Tan, Kay Lin Goh, Wai Chong Ong, Chee Pang Ng, Kee Chuan Goh, Zahid Bonday, Eric T. Sun Molecular Cancer Therapeutics 2010; 9(3); 642-52. Epub 2010 Mar 2. SB939, a novel potent ad orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer Veronica Novotny-Diermayr, Kanda Sangthongpitag, Chang Yong Hu, Xiao Feng Wu, Nina Sausgruber, Pauline Yeo, Gediminas Greicius, Sven Pettersson, Ai Leng Liang, Yung Kiang Loh, Zahid Bonday, Kee Chuan Goh, Hannes Hentze, Stefan Hart, Haishan Wang, Kantharaj Ethirajulu, Jeanette Wood Expert Opinion on Therapeutic Patents 2009; 19(12):1727-1757 New patented histone deacetylase inhibitors Haishan Wang & Brian W Dymock AACR 100th Annual Meeting, Denver, April 2009 Pharmacokinetic/Pharmacodynamic (PK/PD) relationships for novel HDAC inhibitors in a mouse xenograft HCT116 tumor model (Abstract No. 2924) Ramesh Jayaraman, Mohammed Khalid Pasha, Pauline Yeo, Kanda Sangthongpitag, Haishan Wang, Hannes Hentze, Veronica Novotny-Diermayr, Jeanette Wood and Kantharaj Ethirajulu AACR 100th Annual Meeting, Denver, April 2009 Novel potent and selective mTOR/PI3K inhibitors that inhibit tumor growth in animal models through efficient and sustained shut down of the PI3K/Akt signaling pathway (Abstract No. 3710) Zahid Bonday, Meredith Williams, Harish Nagaraj, Anders Poulsen, Hannes Hentze, Di Zhong Chen, Stéphanie Blanchard, Stefan Hart, Kee Chuan Goh, Kay Lin Goh, Miah Kiat Goh, Ramesh Jayaraman, Ai Leng Liang, Yung Kiang Loh, Wai Chung Ong, Chang Kai Soh, Mohammed Khalid Pasha, Brian Dymock, Kantharaj Ethirajulu, Jeanette Wood Bioorganic & Medicinal Chemistry Letters 2009; 19(5): 1403 – 1408 N-Hydroxy-1,2-disubsitituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity Haishan Wang, Niefang Yu, Hongyan Song, Dizhong Chen, Yong Zou, Weiping Deng, Pek Ling Lye, Joyce Chang, Melvin Ng, Stéphanie Blanchard, Eric T. Sun, Kanda Sangthongpitag, Xukun Wang, Kee Chuan Goh, Xiaofeng Wu, Hwee Hoon Khng, Lijuan Fang, Siok Kun Goh, Wai Chung Ong, Zahid Bonday, Walter Stünkel, Anders Poulsen, Michael Entzeroth
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